Bibliography on Prions, BSE and Encephalopathies

Recent Articles
Last 4 months, sorted by author. (Last modified: January 27, 1998)

Genetics of prions. 1997. Prusiner, S. B. and M. R. Scott. Annu.Rev.Genet. 31:139-175.

Prion diseases - BSE and prions: Uncertainties about the agent. 1998. Chesebro, B. Science 279:42-43.

Inactivation of the 22A strain of scrapie agent by autoclaving in sodium hydroxide. 1997. Taylor, D. M., K. Fernie, and I. McConnell. Vet.Microbiol. 58:87-91.

The effect of formic acid on BSE and scrapie infectivity in fixed and unfixed brain-tissue. 1997. Taylor, D. M., J. M. Brown, K. Fernie, and I. McConnell. Vet.Microbiol. 58:167-174.

Interaction of prion peptide HuPrP106-126 with nucleic acid. 1997. Nandi, P. K. Arch.Virol. 142:2537-2545.

The 118-135 peptide lot the human prion protein forms amyloid fibrils and induces liposome fusion. 1997. Pillot, T., L. Lins, M. Goethals, B. Vanloo, J. Baert, J. Vandekerckhove, M. Rosseneu, and R. Brasseur. J.Mol.Biol. 274:381-393.

Latest results on prion proteins. 1997. Bradbury, J. Lancet 350:1827-1827.

New prion link. 1997. Voelker, R. JAMA 278:2053-2053.

Second passage of a US scrapie agent in cattle. 1997. Cutlip, R. C., J. M. Miller, and H. D. Lehmkuhl. J.Comp.Pathol. 117:271-275.

A wild-type prion protein does not acquire properties of the scrapie isoform when coexpressed with a mutant prion protein in cultured cells. 1997. Lehmann, S., N. Daude, and D. A. Harris. Mol.Brain Res. 52:139-145.

Spongiform encephalopathies - B lymphocytes and neuroinvasion. 1997. Brown, P. Nature 390:662-663.

The cellular prion protein binds copper in vivo. 1997. Brown, D. R., K. F. Qin, J. W. Herms, A. Madlung, J. Manson, R. Strome, P. E. Fraser, T. Kruck, A. vonBohlen, W. SchulzSchaeffer, A. Giese, D. Westaway, and H. Kretzschmar. Nature 390:684-687.

A crucial role for B cells in neuroinvasive scrapie. 1997. Klein, M. A., R. Frigg, E. Flechsig, A. J. Raeber, U. Kalinke, H. Bluethmann, F. Bootz, M. Suter, R. M. Zinkernagel, and A. Aguzzi. Nature 390:687-690.

Transmissible spongiform encephalopathies. 1997. Haywood, A. M. N.Engl.J.Med. 337:1821-1828.

Allele identification using immobilized mismatch binding protein: detection and identification of antibiotic-resistant bacteria and determination of sheep susceptibility to scrapie. 1997. Debbie, P., K. Young, L. Pooler, C. Lamp, P. Marietta, and R. Wagner. Nucleic.Acids.Res. 25:4825-4829.

Structure of the recombinant full-length hamster prion protein PrP(29- 231): The N terminus is highly flexible. 1997. Donne, D. G., J. H. Viles, D. Groth, I. Mehlhorn, T. L. James, F. E. Cohen, S. B. Prusiner, P. E. Wright, and H. J. Dyson. Proc.Natl.Acad.Sci.USA 94:13452-13457.

Interactions of the chaperone Hsp104 with yeast Sup35 and mammalian PrP. 1997. Schirmer, E. C. and S. Lindquist. Proc.Natl.Acad.Sci.USA 94:13932-13937.

Chaperone-supervised conversion of prion protein to its protease- resistant form. 1997. DebBurman, S. K., G. J. Raymond, B. Caughey, and S. Lindquist. Proc.Natl.Acad.Sci.USA 94:13938-13943.

Neurodegenerative disease - B cells may propagate prions. 1997. Vogel, G. Science 278:2050-2050.

Nobelists beat adversity to advance science. 1997. Smaglik, P. Scientist. 11:1-

Membrane protein biogenesis: Regulated complexity at the endoplasmic reticulum. 1997. Hegde, R. S. and V. R. Lingappa. Cell 91:575-582.

Human prion proteins expressed in Escherichia coli and purified by high-affinity column refolding. 1997. Zahn, R., C. vonSchroetter, and K. Wuthrich. FEBS Lett. 417:400-404.

Synthetic growth hormone has no inducting effect in the development of a prion disease: An experimental study on the scrapie model in hamsters. 1997. Gregoire, N., J. R. Fraser, J. F. Pellissier, and J. Nicoli. J.Neurol.Sci. 152:224-225.

UK accused over risk of CJD in plasma ... and latest BSE beef ban 'comes too late'. 1997. Butler, D. Nature 390:541-541.

Prions: A new principle in infectious neurodegenerative diseases. Kuru, scrapie and Creutzfeld-Jacob. 1997. Rigler, R. Neuroreport. 8:R3-R5.

Emerging pathogens: Threat and opportunity. 1997. Forrest, D. M. and B. Gushulak. Perspect.Biol.Med. 41:118-124.

Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease. 1997. Diez, M., J. Koistinaho, S. J. Dearmond, D. Groth, S. B. Prusiner, and T. Hokfelt. Proc.Natl.Acad.Sci.USA 94:13267-13272.

Analysis of dam-calf pairs of BSE cases: confirmation of a maternal risk enhancement. 1997. Donnelly, C. A., N. M. Ferguson, A. C. Ghani, J. W. Wilesmith, and R. M. Anderson. Proc.R.Soc.Lond.[Biol.] 264:1647-1656.

Bovine spongiform encephalopathy and early onset variant Creutzfeldt- Jakob disease. 1997. Weissmann, C. and A. Aguzzi. Curr.Opin.Neurobiol. 7:695-700.

A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform. 1997. Peretz, D., R. A. Williamson, Y. Matsunaga, H. Serban, C. Pinilla, R. B. Bastidas, R. Rozenshteyn, T. L. James, R. A. Houghten, F. E. Cohen, S. B. Prusiner, and D. R. Burton. J.Mol.Biol. 273:614-622.

Two possible receptors found for prion proteins. 1997. Bradbury, J. Lancet 350:1603-1603.

Post-exposure prophylaxis after accidental prion inoculation. 1997. Aguzzi, A. and J. Collinge. Lancet 350:1519-1520.

Prion discoverer receives Nobel Prize. 1997. Can.Med.Assoc.J. 157:1336-1337.

A prion primer. 1997. Cashman, N. R. Can.Med.Assoc.J. 157:1381-1385.

Notifying patients exposed to blood products associated with Creutzfeldt-Jakob disease: integrating science, legal duties and ethical mandates. 1997. Caulfield, T., J. Dossetor, L. Boshkov, J. Hannon, D. Sawyer, and G. Robertson. Can.Med.Assoc.J. 157:1389-1392.

Creutzfeldt-Jakob disease: the Canadian situation. 1997. Stratton, E. Can.Med.Assoc.J. 157:1405-1406.

Problems of BSE-contaminated foods and other beef products. 1997. Rabenau, H. F. and H. W. Doerr. Dtsch.Med.Wochenschr. 122:1402-1402.

Propagation of prion strains through specific conformers of the prion protein. 1997. Scott, M. R., D. Groth, J. Tatzelt, M. Torchia, P. Tremblay, S. J. Dearmond, and S. B. Prusiner. J.Virol. 71:9032-9044.

Late treatment with polyene antibiotics can prolong the survival time of scrapie-infected animals. 1997. Demaimay, R., K. T. Adjou, V. Beringue, S. Demart, C. I. Lasmezas, J. P. Deslys, M. Seman, and D. Dormont. J.Virol. 71:9685-9689.

A prion-linked psychiatric disorder. 1997. Samaia, H. B., J. D. Mari, H. P. Vallada, R. P. Moura, A. J. Simpson, and R. R. Brentani. Nature 390:241-241.

The prion model for [URE3] of yeast: Spontaneous generation and requirements for propagation. 1997. Masison, D. C., M. L. Maddelein, and R. B. Wickner. Proc.Natl.Acad.Sci.USA 94:12503-12508.

Meeting briefs - The big easy serves up a feast to visiting neuroscientists - Rat model for Gulf War syndrome? - Protective role for prion protein? 1997. Barinaga, M. Science 278:1404-1405.

Diagnosis of Creutzfeldt-Jakob disease and related human spongiform encephalopathies. 1997. Weber, T., M. Otto, M. Bodemer, and I. Zerr. Biomed.Pharmacother. 51:381-387.

Prion protein aggregation reverted by low temperature in transfected cells carrying a prion protein gene mutation. 1997. Singh, N., G. Zanusso, S. G. Chen, H. Fujioka, S. Richardson, P. Gambetti, and R. B. Petersen. J.Biol.Chem. 272:28461-28470.

Life-time diagnosis of prion transmissive encephalopathies. 1997. Roikhel, V. M., G. I. Fokina, L. M. Kondakova, S. G. Sobolev, V. V. Pogodina, D. N. Dzhibladze, V. V. Gnezditsky, Y. M. Kashina, V. V. Peresedov, Y. B. Sungurov, A. I. Kugoyev, R. P. Chaikovskaya, Y. V. Konovalova, I. Y. Shitikova, and I. A. Zavalishin. Vopr.Virusol. 42:203-205.

BSE and Britain's CJD outbreak: definitive link established. 1997. Brown, C. J. Can.Med.Assoc.J. 157:1194-1194.

Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie. 1997. Raeber, A. J., R. E. Race, S. Brandner, S. A. Priola, A. Sailer, R. A. Bessen, L. Mucke, J. Manson, A. Aguzzi, M. B. Oldstone, C. Weissmann, and B. Chesebro. EMBO J. 16:6057-6065.

Nobel prize to Stanley Prusiner for prion discovery. 1997. Stephenson, J. JAMA 278:1479-1479.

pH-dependent stability and conformation of the recombinant human prion protein PrP(90-231). 1997. Swietnicki, W., R. Petersen, P. Gambetti, and W. K. Surewicz. J.Biol.Chem. 272:27517-27520.

Chemical inactivators as sterilization agents for bovine collagen materials. 1997. Doillon, C. J., R. Drouin, M. F. Cote, N. Dallaire, J. F. Pageau, and G. Laroche. J.Biomed.Mater.Res. 37:212-221.

Diffuse thalamic degeneration in fatal familial insomnia. A morphometric study. 1997. Macchi, G., G. Rossi, A. L. Abbamondi, G. Giaccone, D. Mancia, F. Tagliavini, and O. Bugiani. Brain Res. 771:154-158.

Prion protein is necessary for latent learning and long-term memory retention. 1997. Nishida, N., S. Katamine, K. Shigematsu, A. Nakatani, N. Sakamoto, S. Hasegawa, R. Nakaoke, R. Atarashi, Y. Kataoka, and T. Miyamoto. Cell Mol.Neurobiol. 17:537-545.

Putative neurosurgical transmission of Creutzfeldt-Jakob disease with analysis of donor and recipient: agent strains. 1997. ElHachimi, K. H., M. P. Chaunu, L. Cervenakova, P. Brown, and J. F. Foncin. C.R.Acad.Sci.[III.] 320:319-328.

Effect of flupirtine on bcl-2 and glutathione level in neuronal cells treated in vitro with the prion protein fragment (PrP 106-126). 1997. Perovic, S., H. C. Schroder, G. Pergande, H. Ushijima, and W. E. Muller. Exp.Neurol. 147:518-524.

Elevation of apolipoprotein E in the CSF of cattle affected by BSE. 1997. Hochstrasser, D. F., S. Frutiger, M. R. Wilkins, G. Hughes, and J. C. Sanchez. FEBS Lett. 416:161-163.

Prion (PrPSc)-specific epitope defined by a monoclonal antibody. 1997. Korth, C., B. Stierli, P. Streit, M. Moser, O. Schaller, R. Fischer, W. SchulzSchaeffer, H. Kretzschmar, A. Raeber, U. Braun, F. Ehrensperger, S. Hornemann, R. Glockshuber, R. Riek, M. Billeter, K. Wuthrich, and B. Oesch. Nature 390:74-77.

Genetic interpretation of heightened risk of BSE in offspring of affected dams. 1997. Ferguson, N. M., C. A. Donnelly, M. E. Woolhouse, and R. M. Anderson. Proc.R.Soc.Lond.[Biol.] 264:1445-1455.

Prions and their biophysical background. 1997. Riesner, D. Biophys.Chem. 66:259-268.

The prion hypothesis is finally accepted by the establishment. 1997. Josefson, D. Br.Med.J. 315:972-972.

Yeast prions: Inheritance by seeded protein polymerization? 1997. Lansbury, P. T. Curr.Biol. 7:R617-R619.

Sequencing analysis of prion genes from red deer and camel. 1997. Kaluz, S., M. Kaluzova, and A. P. Flint. Gene 199:283-286.

Recent trends in the BSE epidemic. 1997. Donnelly, C. A., A. C. Ghani, N. M. Ferguson, and R. M. Anderson. Nature 389:903-903.

The human prion diseases: from neuropathology to pathobiology and molecular genetics. 1997. Budka, H., J. A. Hainfellner, K. Jellinger, R. Kleinert, H. Maier, P. Pilz, R. Sciot, J. J. Martin, M. BojsenMoller, H. Laursen, P. StTeglbjaerg, M. Haltia, J. Kovanen, M. B. Delisle, D. Dormont, C. Lasmezas, F. Gray, J. J. Hauw, D. Seilhean, N. Heldt, J. Mikol, C. Vital, J. F. Foncin, K. ElHachimi, N. Kopp, M. Bergmann, T. Bilzer, J. CervosNavarro, H. Diringer, W. Feiden, H. H. Goebel, J. Bohl, F. Gullotta, K. Jendroska, H. A. Kretzschmar, R. P. Linke, R. Meyermann, J. W. Boellaard, P. Mehraein, W. Schlote, J. M. Schroder, R. Schroder, B. Volk, G. F. Walter, A. Hori, O. D. Wiestler, S. J. Balloyannis, P. Davaki, and E. Patsouris. Neuropathol.Appl.Neurobiol. 23:416-422.

T-lymphocyte activation and the cellular form of the prion protein. 1997. Mabbott, N. A., K. L. Brown, J. Manson, and M. E. Bruce. Immunology 92:161-165.

Severely combined immunodeficient (SCID) mice resist infection with bovine spongiform encephalopathy. 1997. Brown, K. L., K. Stewart, M. E. Bruce, and H. Fraser. J.Gen.Virol. 78:2707-2710.

S-100 protein concentration in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. 1997. Otto, M., H. Stein, A. Szudra, I. Zerr, M. Bodemer, O. Gefeller, S. Poser, H. A. Kretzschmar, M. Mader, and T. Weber. J.Neurol. 244:566-570.

A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis. 1997. Schatzl, H. M., L. Laszlo, D. M. Holtzman, J. Tatzelt, S. J. Dearmond, R. I. Weiner, W. C. Mobley, and S. B. Prusiner. J.Virol. 71:8821-8831.

RNA aptamers specifically interact with the prion protein PrP. 1997. Weiss, S., D. Proske, M. Neumann, M. H. Groschup, H. A. Kretzschmar, M. Famulok, and E. L. Winnacker. J.Virol. 71:8790-8797.

Prusiner awarded the Nobel prize for work on prions. 1997. Bonn, D. and A. Ault. Lancet 350:1079-1079.

Prion research: the next frontiers. 1997. Aguzzi, A. and C. Weissmann. Nature 389:795-798.

Syrian hamster prion protein (PrPC) is expressed in photoreceptor cells of the adult retina. 1997. Chishti, M. A., R. Strome, G. A. Carlson, and D. Westaway. Neurosci.Lett. 234:11-14.

Prion protein (PrP) is not involved in the pathogenesis of spongiform encephalopathy in transgenic mice expressing interleukin-6 in the brain. 1997. Castelnau, P. A., I. L. Campbell, and H. C. Powell. Neurosci.Lett. 234:15-18.

Agents of new variant CJD and BSE are identical. 1997. Wise, J. Br.Med.J. 315:831-831.

Cerebral and cerebellar atrophy on serial magnetic resonance imaging in an initially symptom free subject at risk of familial prion disease. 1997. Fox, N. C., P. A. Freeborough, K. F. Mekkaoui, J. M. Stevens, and M. N. Rossor. Br.Med.J. 315:856-857.

Therapeutical approaches to transmissible spongiform encephalopathies (TSE): the case of Amphotericin-B. 1996. Calissano, M., R. Petraroli, and M. Pocchiari. J.Biol.Regulat.Homeost.Agent. 10:69-71.

Panencephalopathic type of Creutzfeldt-Jakob disease associated with cadaveric dura mater graft. 1997. Yamada, M., Y. Itoh, N. Suematsu, M. Matsushita, and E. Otomo. J.Neurol.Neurosurg.Psychiatry 63:524-527.

Brain biopsy and patients with atypical presentations of sporadic Creutzfeldt-Jakob disease. 1997. Whittle, I. R., R. G. Will, and J. W. Ironside. J.Neurol.Neurosurg.Psychiatry 63:547-548.

Distribution of parvalbumin-immunoreactive neurons in brain correlates with hippocampal and temporal cortical pathology in Creutzfeldt-Jakob disease. 1997. Guentchev, M., J. A. Hainfellner, G. R. Trabattoni, and H. Budka. J.Neuropathol.Exp.Neurol. 56:1119-1124.

Nobel prize - Prusiner recognized for once-heretical prion theory. 1997. Vogel, G. Science 278:214-214.

Prion diseases and the BSE crisis. 1997. Prusiner, S. B. Science 278:245-251.

A hypothesis describing a potential link between molecular structure and TSE strains. 1997. Warwicker, J. Biochem.Biophys.Res.Commun. 238:185-190.

Differential resistance to proteinase K digestion of the yeast prion- like (Ure2p) protein synthesized in vitro in wheat germ extract and rabbit reticulocyte lysate cell-free translation systems. 1997. Komar, A. A., T. Lesnik, C. Cullin, E. Guillemet, R. Ehrlich, and C. Reiss. FEBS Lett. 415:6-10.

Genetic and environmental factors affecting the de novo appearance of the [PSI+] prion in Saccharomyces cerevisiae. 1997. Derkatch, I. L., M. E. Bradley, P. Zhou, Y. O. Chernoff, and S. W. Liebman. Genetics 147:507-519.

Increase of intracellular free Ca2+ in microglia activated by prion protein fragment. 1997. Herms, J. W., A. Madlung, D. R. Brown, and H. A. Kretzschmar. Glia 21:253-257.

Latest results are the strongest yet to link nvCJD with BSE. 1997. Bradbury, J. Lancet 350:1007-1007.

New variant Creutzfeldt-Jakob disease: neurological features and diagnostic tests. 1997. Zeidler, M., G. E. Stewart, C. R. Barraclough, D. E. Bateman, D. Bates, D. J. Burn, A. C. Colchester, W. Durward, N. A. Fletcher, S. A. Hawkins, J. M. Mackenzie, and R. G. Will. Lancet 350:903-907.

Nobel panel rewards prion theory after years of heated debate. 1997. Coles, H. Nature 389:529-529.

Differential allelic expression of PrP mRNA in carriers of the E200K mutation. 1997. Rosenmann, H., M. Halimi, I. Kahana, I. Biran, and R. Gabizon. Neurology 49:851-856.

Mad cow disease - New studies affirm BSE-human link. 1997. Williams, N. Science 278:31-31.

Chemistry and molecular biology of transmissible spongiform encephalopathies. 1997. Edenhofer, F., S. Weiss, E. L. Winnacker, and M. Famulok. Angew.Chem.Int.Ed. 36:1675-1694.

Prion diseases (transmissible spongiform encephalopathies): A review. 1997. Hansen, N. J. Endoscopy. 29:584-592.

Use of capillary sodium dodecyl sulfate gel electrophoresis to detect the prion protein extracted from scrapie-infected sheep. 1997. Schmerr, M. J., A. Jenny, and R. C. Cutlip. J.Chromatogr.B. 697:223-229.

Antigenic features of prion proteins of sheep and of other mammalian species. 1997. Groschup, M. H., S. Harmeyer, and E. Pfaff. J.Immunol.Methods 207:89-101.

Transmission of Creutzfeldt-Jakob disease via a corneal transplant. 1997. Heckmann, J. G., C. J. Lang, F. Petruch, A. Druschky, C. Erb, P. Brown, and B. Neundorfer. J.Neurol.Neurosurg.Psychiatry 63:388-390.

Not the last word on the BSE crisis. 1997. Nature 389:423-423.

Human BSE. 1997. Almond, J. and J. Pattison. Nature 389:437-438.

The same prion strain causes vCJD and BSE. 1997. Hill, A. F., M. Desbruslais, S. Joiner, K. C. Sidle, I. Gowland, J. Collinge, L. J. Doey, and P. Lantos. Nature 389:448-450.

Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent. 1997. Bruce, M. E., R. G. Will, J. W. Ironside, I. McConnell, D. Drummond, A. Suttie, L. McCardle, A. Chree, J. Hope, C. Birkett, S. Cousens, H. Fraser, and C. J. Bostock. Nature 389:498-501.

Unaltered susceptibility to BSE in transgenic mice expressing human prion protein (Vol 378, pg 779, 1995). 1997. Collinge, J., M. S. Palmer, K. C. Sidle, A. F. Hill, I. Gowland, J. Meads, E. Asante, R. Bradley, L. J. Doey, and P. L. Lantos. Nature 389:526-526.

Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation. 1997. Kaneko, K., L. Zulianello, M. Scott, C. M. Cooper, A. C. Wallace, T. L. James, F. E. Cohen, and S. B. Prusiner. Proc.Natl.Acad.Sci.USA 94:10069-10074.

Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform. 1997. James, T. L., H. Liu, N. B. Ulyanov, S. FarrJones, H. Zhang, D. G. Donne, K. Kaneko, D. Groth, I. Mehlhorn, S. B. Prusiner, and F. E. Cohen. Proc.Natl.Acad.Sci.USA 94:10086-10091.

BSE and human prion disease. 1997. Longhurst, J. G. Br.J.Psychiatry 171:290-290.

The risk of bovine spongiform encephalopathy ('mad cow disease') to human health. 1997. Brown, P. JAMA 278:1008-1011.

The nature of transmission in prion diseases. 1997. Ridley, R. M. and H. F. Baker. Neuropathol.Appl.Neurobiol. 23:273-280.

Principles and practice of 'high risk' brain banking. 1997. Bell, J. E. and J. W. Ironside. Neuropathol.Appl.Neurobiol. 23:281-288.

Human prion diseases and bovine spongiform encephalopathy (BSE). 1997. Collinge, J. Hum.Mol.Genet. 6:1699-1705.

General Bibliography

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Spongiform encephalopathies - Between cows and monkeys. 1996;Aguzzi A. Nature 381(6585):734-5.

Pathogenesis of spongiform encephalopathies: An update. 1996;Aguzzi A. Int Arch Allergy Immunol 110(2):99-106.

Transgenic and knockout mice in the study of neurodegenerative diseases. 1996;Aguzzi A, Brandner S, Marino S, Steinbach JP. J Molecular Med Jmm 74(3):111-26.

Spongiform encephalopathies - A suspicious signature. 1996;Aguzzi A, Weissmann C. Nature 383(6602):666-7.

Transmission dynamics and epidemiology of BSE in British cattle. 1996;Anderson RM, Donnelly CA, Ferguson NM, Woolhouse MEJ, Watt CJ, Udy HJ, MaWhinney S, Dunstan SP, Southwood TRE, Wilesmith JW, et al. Nature 382(6594):779-88.

Demyelinating peripheral neuropathy with Creutzfeldt-Jakob disease and mutation at codon 200 of the prion protein gene. 1996;Antoine JC, Laplanche JL, Mosnier JF, Beaudry P, Chatelain J, Michel D. Neurology 46(4):1123-7.

Immunohistochemical detection of prion protein in lymphoid tissues of sheep, cattle, and humans. 1996;Aryu SC. J Clin Microbiol 34(10):2639

What went wrong in BSE? From prion disease to public disaster. 1996;Baker HF, Ridley RM. Brain Res Bull 40(4):237-44.

Creutzfeldt-Jakob disease and bovine spongiform encephalopathy -Study so far provides no evidence for maternal and horizontal transmission. 1996;Baker HF, Ridley RM. Br Med J 312(7034):843

Spontaneous spongiform encephalopathy in a monkey. 1996;Baker HF, Ridley RM, Wells GAH, Ironside JW. Lancet 348(9032):955-6.

Polymorphism at codon 129 or codon 219 of PRNP and clinical heterogeneity in a previously unreported family with Gerstmann-Straussler-Scheinker disease (PrP-P102L mutation). 1996;Barbanti P, Fabbrini G, Salvatore M, Petraroli R, Cardone F, Maras B, Equestre M, Macchi G, Lenzi GL, Pocchiari M. Neurology 47(3):734-41.

Sequential appearance and accumulation of pathognomonic markers in the central nervous system of hamsters orally infected with scrapie. 1996;Beekes M, Baldauf E, Diringer H. J Gen Virol 77:1925-1934:1925-34.

Neuropathological diagnosis of human prion disease - PrP immunocytochemical techniques. 1996;Bell JE. Prion Diseases 59-83-83.

Creutzfeldt-Jakob disease and bovine spongiform encephalopathy -Incidence of bovine spongiform encephalopathy is higher in cows born after feed ban. 1996;Bennett M. Br Med J 312(7034):843-4.

Evidence for an early inflammatory response in the central nervous system of mice with scrapie. 1996;Betmouni S, Perry VH, Gordon JL. Neuroscience 74(1):1-5.

Spontaneous spongiform encephalopathy in a monkey - Reply. 1996;Bons N. Lancet 348(9032):956

Spontaneous spongiform encephalopathy in a young adult rhesus monkey. 1996;Bons N, MestreFrances N, Charnay Y, Salmona M, Tagliavini F. C R Acad Sci [III] 319(8):733-6.

Spontaneous spongiform encephalopathy in a young adult rhesus monkey. 1996;Bons N, MestreFrances N, Charnay Y, Tagliavini F. Lancet 348(9019):55

Loss of functional prion protein: A role in prion disorders? 1996;Borchelt DR, Sisodia SS. Chem Biol 3(8):619-21.

PrP genotype contributes to determining survival times of sheep with natural scrapie. 1996;Bossers A, Schreuder BEC, Muileman IH, Belt PBGM, Smits MA. J Gen Virol 77:2669-2673:2669-73.

Electrophoretic analysis of nucleic acids isolated from scrapie-infected hamster brain. 1996;Bountiff L, Levantis P, Oxford J. J Gen Virol 77:2371-2378:2371-8.

Maternal transmission of BSE demonstrated in cattle. 1996;Bradbury J. Lancet 348(9024):393

Normal host prion protein necessary for scrapie-induced neurotoxicity. 1996;Brandner S, Isenmann S, Raeber A, Fischer M, Sailer A, Kobayashi Y, Marino S, Weissmann C, Aguzzi A. Nature 379(6563):339-43.

Role of microglia and host prion protein in neurotoxicity of a prion protein fragment. 1996;Brown DR, Schmidt B, Kretzschmar HA. Nature 380(6572):345-7.

A neurotoxic prion protein fragment enhances proliferation of microglia but not astrocytes in culture. 1996;Brown DR, Schmidt B, Kretzschmar HA. Glia 18(1):59-67.

Transmissible cerebral amyloidosis. 1996;Brown P. J Neural Transmission Suppl (47):219-29.

Environmental causes of human spongiform encephalopathy. 1996;Brown P. Prion Diseases 139-154-154.

Bovine spongiform encephalopathy and Creutzfeldt-Jakob disease -The link is unproved, but no better explanation is presently forthcoming. 1996;Brown P. Br Med J 312(7034):790-1.

Inactivation of the causal agents of Creutzfeldt-Jakob disease and other human prion diseases - Reply. 1996;Brown P, Tateishi J, Budka H. Brain Pathol 6(2):198

Strain typing studies of scrapie and BSE. 1996;Bruce ME. Prion Diseases 223-236-236.

Tissue handling in suspected Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases). 1996;Budka H, Aguzzi A, Brown P, Brucher JM, Bugiani O, Collinge J, Diringer H, Gullotta F, Haltia M, Hauw JJ, et al. Pathologe 17(2):171-5.

The Human Prion Diseases: Neuropathology, Pathobiology and Molecular Genetics - Vienna, Austria, 16 October 1995. 1996;Budka H, Hainfellner HA. Neuropathol Appl Neurobiol 22(2):171-3.

Replication of IFDO on a chemically defined medium. 1996;Burdon DW, Wakeman JG, Nayyar P. J Med Microbiol 45(1):10-5.

BSE maternal transmission results may be released soon. 1996;Butler D. Nature 381(6585):724

Funding row delays Brussels BSE research. 1996;Butler D. Nature 383(6601):565

Prion research programme proposed. 1996;Butler D. Nature 381(6585):724

BSE researchers bemoan 'ministry secrecy'. 1996;Butler D. Nature 383(6600):467-8.

Slow release of data adds to BSE confusion. 1996;Butler D. Nature 380(6573):370

Statistics suggest BSE now 'Europe-wide'. 1996;Butler D. Nature 382(6586):4

French action aims to quell BSE fears. 1996;Butler D. Nature 382(6586):5

A prion disease with a novel 96-base pair insertional mutation in the prion protein gene. 1996;Campbell TA, Palmer MS, Will RG, Gibb WRG, Luthert PJ, Collinge J. Neurology 46(3):761-6.

BSE: The questions that need answers. 1996;Carr K. Nature 380(6572):273-4.

Early pathologic and biochemical changes in Creutzfeldt- Jakob disease: Study of brain biopsies. 1996;Castellani R, Parchi P, Stahl J, Capellari S, Cohen M, Gambetti P. Neurology 46(6):1690-3.

Methods for studying prion protein (PrP) metabolism and the formation of protease-resistant PrP in cell culture and cell-free systems. 1996;Caughey B, Kocisko DA, Priola SA, Raymond GJ, Race RE, Bessen RA, Lansbury PT, Chesebro B. Prion Diseases 285-299-299.

Aggregates of scrapie-associated prion protein induce the cell-free conversion of protease-sensitive prion protein to the protease-resistant state. 1995;Caughey B, Kocisko DA, Raymond GJ, Lansbury PT. Chem Biol 2(12):807-17.

Is hereditary inclusion body myopathy a ''familial prion disease''? 1996;Cervenakova L, Sivakumar K, Nagle J, Dalakas MC, Goldfarb LG. Ann Neurol 40(1):128

Fatal insomnia in a case of familial Creutzfeldt-Jakob disease with the codon 200(Lys) mutation. 1996;Chapman J, Arlazoroff A, Goldfarb LG, Cervenakova L, Neufeld MY, Werber E, Herbert M, Brown P, Gajdusek DC, Korczyn AD. Neurology 46(3):758-61.

BSE a specific bovine disease? 1996;Chastel CE. Nature 381(6581):360

Clusterin (SGP-2) induction in rat astroglial cells exposed to prion protein fragment 106-126. 1996;Chiesa R, Angeretti N, Lucca E, Salmona M, Tagliavini F, Bugiani O, Forloni G. Eur J Neurosci 8(3):589-97.

Familial Creutzfeldt-Jakob disease with a five-repeat octapeptide insert mutation. 1996;Cochran EJ, Bennett DA, Cervenakova L, Kenney K, Bernard B, Foster NL, Benson DF, Goldfarb LG, Brown P. Neurology 47(3):727-33.

Bovine spongiform encephalopathy - Disease is due to pressure on farming industry - Doctors are less likely than patients to have stopped eating. 1996;Cohen H. Br Med J 313(7050):171-2.

Hippocampal slices from prion protein null mice: Disrupted Ca2+-activated K+ currents. 1996;Colling SB, Collinge J, Jefferys JGR. Neurosci Lett 209(1):49-52.

New diagnostic tests for prion diseases. 1996; Collinge J. N Engl J Med 335(13):963-5.

Prion protein gene analysis in new variant cases of Creutzfeldt-Jakob disease. 1996; Collinge J, Beck J, Campbell T, Estibeiro K, Will RG. Lancet 348(9019):56

A new variant of prion disease. 1996; Collinge J, Rossor M. Lancet 347(9006):916-7.

Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD. 1996; Collinge J, Sidle KCL, Meads J, Ironside J, Hill AF. Nature 383(6602):685-90.

Iatrogenic and zoonotic Creutzfeldt-Jakob disease: The Australian perspective. 1996;Collins S, Masters CL. Med J Aust 164(10):598-602.

Bovine spongiform encephalopathy - Disease is due to pressure on farming industry. 1996;Dealler S. Br Med J 313(7050):171

A matter for debate: The risk of bovine spongiform encephalopathy to humans posed by blood transfusion in the UK. 1996;Dealler S. Transfusion Med 6(3):217-22.

Replication and pathogenicity after intranasal and intracranial inoculation of swine with a recombinant pseudorabies virus containing a deletion at the UL/IR junction. 1996;Dean HJ, Miller JM, Ackermann MR, Gao XY, Anderson LL, Jacobson CD, Cheung AK. Virology 223(1):19-28.

BSE agent: There may be even more trouble ahead. 1996;Delamonte T. Br Med J 313(7051):189-90.

Human spongiform encephalopathy - Clinical presentation and diagnostic tests. 1996;deSilva R. Prion Diseases 15-33-33.

BSE linked to new variant of CJD in humans. 1996;Dillner L. Br Med J 312(7034):795

Emerging problems in prion disease. 1996;Dodelet V, Ricketts M, Cashman NR. Can Med Assoc J 155(5):549-51.

The biology of unconventional, transmissible agents, or prions. 1996;Dormont D. C R Acad Sci [III] 319(7):549-53.

Creutzfeldt-Jakob disease and transplantation: Facts and fables. 1996;Dormont D. Transplant Proc 28(5):2931-3.

Last news: BSE in the turmoil. 1996;Dormont D, Bursaux E. M S Med Sci 12(5):673-5.

Visualization of viral candidate cDNAs in infectious brain fractions from Creutzfeldt-Jakob disease by representational difference analysis. 1996;Dron M, Manuelidis L. J Neurovirology 2(4):240-8.

Prion protein PrPc interacts with molecular chaperones of the Hsp60 family. 1996;Edenhofer F, Rieger R, Famulok M, Wendler W, Weiss S, Winnacker EL. J Virol 70(7):4724-8.

Multiple roles for PrP in the prion diseases. 1996;Estibeiro JP. Trends Neurosci 19(7):257-8.

Protease-resistant PrP deposition in brain and non-central nervous system tissues of a murine model of bovine spongiform encephalopathy. 1996;Farquhar CF, Dornan J, Moore RC, Somerville RA, Tunstall AM, Hope J. J Gen Virol 77:1941-1946:1941-6.

Creutzfeldt-Jakob disease and bovine spongiform encephalopathy -Magnetic resonance imaging may have a role in diagnosing Creutzfeldt-Jakob disease. 1996;Featherstone T. Br Med J 312(7024):180

Keeping an open mind about prions. 1996;Finkel E. Lancet 348(9023):326

Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. 1996;Fischer M, Rulicke T, Raeber A, Sailer A, Moser M, Oesch B, Brandner S, Aguzzi A, Weissmann C. EMBO J 15(6):1255-64.

Creutzfeldt-Jakob disease and bovine spongiform encephalopathy -Scientists who inflame public anxieties must share responsibility for resulting panic. 1996;Fitzpatrick M. Br Med J 312(7037):1037

Prion disease and blood transfusion. 1996;Flanagan P, Barbara JAJ. Transfusion Med 6(3):213-5.

Apoptosis-mediated neurotoxicity induced by beta-amyloid and PRP fragments. 1996;Forloni G, Bugiani O, Tagliavini F, Salmona M. Mol Chem Neuropathol 28(1-3):163-71.

Amyloid in Alzheimer's disease and prion-related encephalopathies: Studies with synthetic peptides. 1996;Forloni G, Tagliavini F, Bugiani O, Salmona M. Prog Neurobiol 49(4):287-315.

Mouse inoculation studies reveal no transmissible agent in amyotrophic lateral sclerosis. 1996;Fraser H, Behan W, Chree A, Crossland G, Behan P. Brain Pathol 6(2):89-99.

Replication of scrapie in spleens of SCID mice follows reconstitution with wild-type mouse bone marrow. 1996;Fraser H, Brown KL, Stewart K, McConnell I, McBride P, Williams A. J Gen Virol 77:1935-1940:1935-40.

Infectivity in extraneural tissues following intraocular scrapie infection. 1996;Fraser JR. J Gen Virol 77:2663-2668:2663-8.

Creutzfeldt-Jakob disease and bovine spongiform encephalopathy -Scrapie can be transmitted to mice by instillation of inoculum into the conjunctiva. 1996;Fraser JR, Foster JD, Fraser H. Br Med J 312(7024):181

A Japanese case of Creutzfeldt-Jakob disease with a point mutation in the prion protein gene at codon 210. 1996;Furukawa H, Kitamoto T, Hashiguchi H, Tateishi J. J Neurol Sci 141(1-2):120-2.

Insoluble wild-type and protease-resistant mutant prion protein in brains of patients with inherited prion disease. 1996;Gabizon R, Telling G, Meiner Z, Halimi H, Kahana I, Prusiner SB. Nature Med 2(1):59-64.

Fatal familial insomnia: Behavioral and cognitive features. 1996;Gallassi R, Morreale A, Montagna P, Cortelli P, Avoni P, Castellani R, Gambetti P, Lugaresi E. Neurology 46(4):935-9.

Prion diseases, by H.F. Baker, R.M. Ridley. 1996;Gambetti P. Science 273(5278):1052-3.

Prion protein amyloidosis (Vol 6, pg 127, 1996). 1996;Ghetti B, Piccardo P, Frangione B, Bugiani O, Giaccone G, Young K, Prelli F, Farlow MR, Dlouhy SR, Tagliavini F. Brain Pathol 6(3):363

Prion protein hereditary amyloidosis: Parenchymal and vascular. 1996;Ghetti B, Piccardo P, Frangione B, Bugiani O, Giaccone G, Young K, Prelli F, Farlow MR, Dlouhy SR, Tagliavini F. Semin Virol 7(3):189-200.

Prion protein amyloidosis. 1996;Ghetti B, Piccardo P, Frangione B, Bugiani O, Giaccone G, Young K, Prelli F, Farlow MR, Dlouhy SR, Tagliavini F. Brain Pathol 6(2):127-45.

Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: The phenotype of the stop codon 145 mutation in PRNP. 1996;Ghetti B, Piccardo P, Spillantini MG, Ichimiya Y, Porro M, Perini F, Kitamoto T, Tateishi J, Seiler C, Frangione B, et al. Proc Natl Acad Sci USA 93(2):744-8.

Prion phylogeny revisited. 1996;Goldmann W, Hunter N, Somerville R, Hope J. Nature 382(6586):32-3.

Reduction of the infectivity of scrapie agent as a model for BSE in the manufacturing process of Trasylol(R). 1996;Golker CF, Whiteman MD, Gugel KH, Gilles R, Stadler P, Kovatch RM, Lister D, Wisher MH, Calcagni C, Hubner GE. Biologicals 24(2):103-11.

Creutzfeldt-Jakob disease and bovine spongiform encephalopathy -Doctors and scientists must be able to communicate degree of risk ... but members of the public make up their own minds about risks. 1996;Gunasekera KD, Hapgood AI, Harvey EL, Benjamin TRMH, Jachuck MSJ, Jackson ALN, Kronfeld NPA, Manikon MI, Mearns CJ, Mushtaq N, et al. Br Med J 312(7037):1038

Testing for prion protein does not confirm previously reported conjugal CJD. 1996;Hainfellner JA, Jellinger K, Budka H. Lancet 347(9001):616-7.

Creutzfeldt-Jakob disease in Austria. 1996;Hainfellner JA, Jellinger K, Diringer H, Guentchev M, Kleinert R, Pilz P, Maier H, Budka H. J Neurol Neurosurg Psychiatry 61(2):139-42.

Creutzfeldt-Jakob disease and bovine spongiform encephalopathy -Doctors and scientists must be able to communicate degree of risk. 1996;Harrison J. Br Med J 312(7037):1037-8.

Separating the environmental and genetic factors that may be causes of bovine spongiform encephalopathy. 1996;Hau CM, Curnow RN. Philos Trans R Soc Lond [Biol] 351(1342):913-20.

Unconventional infectious agents or PRIONS. 1995;Hauw JJ, Lazarini F, Seilhean D, Camilleri S, Mokhtari K, Duyckaerts C, Henin D. Ann Pathol 15(6):409-14.

Solid-state NMR studies of the prion protein H1 fragment. 1996;Heller J, Kolbert AC, Larsen R, Ernst M, Bekker T, Baldwin M, Prusiner SB, Pines A, Wemmer DE. Protein Sci 5(8):1655-61.

Cytotoxicity of prion protein peptide (PrP106-126) differs in mechanism from the cytotoxic activity of the Alzheimer's disease amyloid peptide, A beta 25-35. 1996;Hope J, Shearman MS, Baxter HC, Chong A, Kelly SM, Price NC. Neurodegeneration 5(1):1-11.

Autonomous and reversible folding of a soluble amino- terminally truncated segment of the mouse prion protein. 1996;Hornemann S, Glockshuber R. J Mol Biol 261(5):614-9.

Spending on BSE research. 1996;Howie I. Nature 383(6597):211

US herd instinct: No mad cows here - Commentary on bovine spongiform encephalopathy. 1996;Hoyle R. Nat Biotechnol 14(5):548-9.

The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies. 1996;Hsich G, Kinney K, Gibbs CJ, Lee KH, Harrington MG. N Engl J Med 335(13):924-30.

Examination of the biological safety of a drug derived from mammalian organs. 1996;Hubner GE, Koch RC, Sprenger KBG, Stadler PJW, Golker CF. Arzneimittelforschung 46(6):657-61.

Genotyping and susceptibility of sheep to scrapie. 1996;Hunter N. Prion Diseases 211-221-221.

Natural scrapie in a closed flock of Cheviot sheep occurs only in specific PrP genotypes. 1996;Hunter N, Foster JD, Goldmann W, Stear MJ, Hope J, Bostock C. Arch Virol 141(5):809-24.

Neuropathological diagnosis of human prion disease -Morphological studies. 1996;Ironside JW. Prion Diseases 35-57-57.

Human prion diseases. 1996;Ironside JW. J Neural Transmission Suppl (47):231-46.

Prion Diseases: Epidemiology and Pathology - Gottingen, Germany, 26-27 October 1995. 1996;Ironside JW. Neuropathol Appl Neurobiol 22(2):173-5.

Is there a human [psi]? 1996;JeanJean O, LeGoff X, Philippe M. C R Acad Sci [III] 319(6):487-92.

Ultrastructural immuno-localization of synthetic prion protein peptide antibodies in 87V murine scrapie. 1996;Jeffrey M, Goodsir CM, Fowler N, Hope J, Bruce ME, McBride PA. Neurodegeneration 5(1):101-9.

Cloning and expression of a Bacillus sp 79-23 cellulase gene. 1996;Jung KH, Chun YC, Lee JC, Kim JH, Yoon KH. Biotechnol Lett 18(9):1077-82.

Cellular prion protein and GABA(A) receptors: No physical association? 1995;Kannenberg K, Groschup MH, Sigel E. Neuroreport 7(1):77-80.

Humanized prion protein knock-in by Cre-induced site- specific recombination in the mouse. 1996;Kitamoto T, Nakamura K, Nakao K, Shibuya S, Shin RW, Gondo Y, Katsuki M, Tateishi J. Biochem Biophys Res Commun 222(3):742-7.

Swiss cull to meet fears of BSE. 1996;Klaffke O. Nature 383(6598):289

Bonn - BSE a matter of perception in Germany. 1996;Klein RA. Lancet 348(9028):675

Partial unfolding and refolding of scrapie-associated prion protein: Evidence for a critical 16-kDa C-terminal domain. 1996;Kocisko DA, Lansbury PT, Caughey B. Biochemistry 35(41):13434-42.

Heightened expression of tumor necrosis factor alpha, interleukin 1 alpha, and glial fibrillary acidic protein in experimental Creutzfeldt-Jakob disease in mice. 1996;Kordek R, Nerurkar VR, Liberski PP, Isaacson S, Yanagihara R, Gajdusek DC. Proc Natl Acad Sci USA 93(18):9754-8.

Phylogenesis of prion protein. 1996;Krakauer DC, Pagel M, Southwood TRE, Zanotto PMD. Nature 380(6576):675

Researchers homing in on mechanisms of encephalopathic diseases. 1996;Kreeger KY. Scientist 10(12):13

Diagnostic criteria for sporadic Creutzfeldt-Jakob disease. 1996;Kretzschmar HA, Ironside JW, Dearmond SJ, Tateishi J. Arch Neurol 53(9):913-20.

Analysis of interaction sites in homo- and heteromeric complexes containing Bcl-2 family members and the cellular prion protein. 1996;Kurschner C, Morgan JI. Mol Brain Res 37(1-2):249-58.

Creutzfeldt-Jakob disease and bovine spongiform encephalopathy -Bovine spongiform encephalopathy is being maintained by vertical and horizontal transmission. 1996;Lacey RW. Br Med J 312(7024):180-1.

The double life of the prion protein. 1996;Lansbury PT, Caughey B. Curr Biol 6(8):914-6.

Immune system-dependent and -independent replication of the scrapie agent. 1996;Lasmezas CI, Cesbron JY, Deslys JP, Demaimay R, Anjou KT, Rioux R, Lemaire C, Locht C, Dormont D. J Virol 70(2):1292-5.

Strain specific and common pathogenic events in murine models of scrapie and bovine spongiform encephalopathy. 1996;Lasmezas CI, Deslys JP, Demaimay R, Adjou KT, Hauw JJ, Dormont D. J Gen Virol 77:1601-1609:1601-9.

BSE transmission to macaques. 1996;Lasmezas CI, Deslys JP, Demaimay R, Adjou KT, Lamoury F, Dormont D, Robain O, Ironside J, Hauw JJ. Nature 381(6585):743-4.

Dynamic component in prion diseases as a result of the ''protein only'' hypothesis. 1996;Laurent M. M S Med Sci 12(6-7):774-85.

Prion diseases and the 'protein only' hypothesis: A theoretical dynamic study. 1996;Laurent M. Biochem J 318:35-39:35-9.

Role of the prion protein in human encephalopathies (vol 12, pg 949, 1996). 1996;Lehmann S. M S Med Sci 12(10):1169

Role of the prion protein in human spongiform encephalopathies. 1996;Lehmann S. M S Med Sci 12(8-9):949-58.

Mutant and infectious prion proteins display common biochemical properties in cultured cells. 1996;Lehmann S, Harris DA. J Biol Chem 271(3):1633-7.

Two mutant prion proteins expressed in cultured cells acquire biochemical properties reminiscent of the scrapie isoform. 1996;Lehmann S, Harris DA. Proc Natl Acad Sci USA 93(11):5610-4.

How do neurons degenerate in transmissible spongiform encephalopathies? 1996;Liberski PP. Mol Chem Neuropathol 28(1-3):245-9.

Microwave treatment enhances the immunostaining of amyloid deposits in both the transmissible and non-transmissible brain amyloidoses. 1996;Liberski PP, Yanagihara R, Brown P, Kordek R, Kloszewska I, Bratosiewicz J, Gajdusek DC. Neurodegeneration 5(1):95-9.

Heat-shock protein 104 expression is sufficient for thermotolerance in yeast. 1996;Lindquist S, Kim G. Proc Natl Acad Sci USA 93(11):5301-6.

Is ataxic gait the predominant presenting manifestation of Creutzfeldt-Jakob disease? Experience of 14 Chinese cases from Taiwan. 1996;Liou HH, Jeng JS, Chang YC, Chen RC, Yip PK. J Neurol Sci 140(1-2):53-60.

Prions prions prions, by S.B. Prusiner. 1996;Livingston K. Science 273(5278):1053

Mice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampus. 1996;Lledo PM, Tremblay P, Dearmond SJ, Prusiner SB, Nicoll RA. Proc Natl Acad Sci USA 93(6):2403-7.

Thermodynamic prediction of conserved secondary structure: Application to the RRE element of HIV, the tRNA-like element of CMV and the mRNA of prion protein. 1996;Luck R, Steger G, Riesner D. J Mol Biol 258(5):813-26.

Spatial reversal learning in preclinical scrapie- inoculated mice. 1996;Lysons AM, Woollard SJ. Neuroreport 7(5):1087-91.

Prion protein genotype and pathological phenotype studies in sporadic Creutzfeldt-Jakob disease. 1996;MacDonald ST, Sutherland K, Ironside JW. Neuropathol Appl Neurobiol 22(4):285-92.

A quantitative and qualitative analysis of prion protein immunohistochemical staining in Creutzfeldt-Jakob disease using four anti prion protein antibodies. 1996;MacDonald ST, Sutherland K, Ironside JW. Neurodegeneration 5(1):87-94.

Bovine spongiform encephalopathy and Creutzfeldt-Jakob disease: Implications for physicians. 1996;MacKnight C, Rockwood K. Can Med Assoc J 155(5):529-36.

PrP-deficient mice in the study of transmissible spongiform encephalopathies. 1996;Manson JC. Prion Diseases 237-249-249.

Infectivity and host responses in Creutzfeldt-Jakob disease. 1996;Manuelidis L, Fritch W. Virology 216(1):46-59.

From alcohol and breast cancer to beef and BSE - Improving our communication of risk. 1996;Marmot M. Am J Public Health 86(7):921-3.

BSE transmission data pose dilemma for UK scientists. 1996;Masood E. Nature 382(6591):483

A new synthesis of 3-oxosapriparaquinone, a diterpene from Salvia prionitis Hance (Labiatae). 1996;Matsumoto T, Takeda Y, Soh K, Matsumura H, Imai S. Chem Pharm Bull Tokyo 44(8):1588-90.

Geneva - BSE fears stir the Swiss. 1996;McGregor A. Lancet 347(9007):1035

Creutzfeldt-Jakob disease and bovine spongiform encephalopathy -Government policy has failed. 1996;McKee M, Roberts JA, Lang T. Br Med J 312(7037):1038

Transmissible mink encephalopathy. 1996;McKenzie D, Bartz JC, Marsh RF. Semin Virol 7(3):201-6.

Bovine spongiform encephalopathy: Its wider meaning for population health - Worldwide intensive meat production is unsustainable. 1996;McMichael AJ. Br Med J 312(7042):1313-4.

High-level expression and characterization of a purified 142-residue polypeptide of the prion protein. 1996;Mehlhorn I, Groth D, Stockel J, Moffat B, Reilly D, Yansura D, Willett WS, Baldwin M, Fletterick R, Cohen FE, et al. Biochemistry 35(17):5528-37.

Putting prions to the test. 1996;Mestel R. Science 273(5272):184

Reactive microglia in Creutzfeldt-Jakob disease. 1995;Muhleisen H, Gehrmann J, Meyermann R. Neuropathol Appl Neurobiol 21(6):505-17.

The nature of the scrapie agent: The virus theory .2. 1996;Narang H. Proc Soc Exp Biol Med 212(3):208-24.

Origin and implications of bovine spongiform encephalopathy. 1996;Narang H. Proc Soc Exp Biol Med 211(4):306-22.

Creutzfeldt-Jakob disease and bovine spongiform encephalopathy -Risk to human populations is remote. 1996;Neilson S. Br Med J 312(7037):1038-9.

Prion replication and secondary nucleation. 1996;Orgel LE. Chem Biol 3(6):413-4.

Effect of scrapie infection on the activity of neuronal nitric-oxide synthase in brain and neuroblastoma cells. 1996;Ovadia H, Rosenmann H, Shezen E, Halimi M, Ofran I, Gabizon R. J Biol Chem 271(28):16856-61.

BSE transmission data cause confusion. 1996;Page G. Nature 382(6590):381

Sequence variation of intron of prion protein gene, crucial for complete diagnostic strategies. 1996;Palmer MS, vanLeeven RH, Mahal SP, Campbell TA, Humphreys CB, Collinge J. Hum Mutat 7(3):280-1.

Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease. 1996;Parchi P, Castellani R, Capellari S, Ghetti B, Young K, Chen SG, Farlow M, Dickson DW, Sima AAF, Trojanowski JQ, et al. Ann Neurol 39(6):767-78.

New topics in familial prion diseases. 1996;Parchi P, Petersen RB, Gambetti P. Semin Virol 7(3):181-7.

Support for the prion hypothesis for inheritance of a phenotypic trait in yeast. 1996;Patino MM, Liu JJ, Glover JR, Lindquist S. Science 273(5275):622-6.

Propagation of the yeast prion-like [psi(+)] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor. 1996;Paushkin SV, Kushnirov VV, Smirnov VN, TerAvanesyan MD. EMBO J 15(12):3127-34.

Semipreparative chromatographic method to purify the normal cellular isoform of the prion protein in nondenatured form. 1996;Pergami P, Jaffe H, Safar J. Anal Biochem 236(1):63-73.

Prion protein released by platelets. 1996;Perini F, Frangione B, Prelli F. Lancet 347(9015):1635-6.

PRP(27-30) is a normal soluble prion protein fragment released by human platelets. 1996;Perini F, Vidal R, Ghetti B, Tagliavini F, Frangione B, Prelli F. Biochem Biophys Res Commun 223(3):572-7.

Effect of the D178N mutation and the codon 129 polymorphism on the metabolism of the prion protein. 1996;Petersen RB, Parchi P, Richardson SL, Urig CB, Gambetti P. J Biol Chem 271(21):12661-8.

Codon 219 polymorphism of PRNP in healthy Caucasians and Creutzfeldt-Jakob disease patients. 1996;Petraroli R, Pocchiari M. Am J Hum Genet 58(4):888-9.

The current state of knowledge concerning bovine spongiform encephalopathy (mad cow disease). 1996;Pilet C. C R Acad Sci [III] 319(7):555-7.

Prion biology and diseases - Laughing cannibals, mad cows, and scientific heresy. 1996;Prusiner SB. Med Res Rev 16(5):487-505.

Introduction: Prion diseases. 1996;Prusiner SB. Semin Virol 7(3):157

Prion diseases of humans and animals. 1996;Prusiner SB, Telling G, Cohen FE, Dearmond SJ. Semin Virol 7(3):159-73.

The UK epidemic of BSE: Slow virus or chronic pesticide-initiated modification of the prion protein .2. An epidemiological perspective. 1996;Purdey M. Med Hypotheses 46(5):445-54.

The UK epidemic of BSE: Slow virus or chronic pesticide-initiated modification of the prion protein? .1. Mechanisms for a chemically induced pathogenesis/transmissibility. 1996;Purdey M. Med Hypotheses 46(5):429-43.

Prion function and dysfunction: A structure-based scenario. 1996;Radulescu RT, Korth C. Med Hypotheses 46(3):225-8.

To what extent is strain variation evidence for an independent genome in the agent of the transmissible spongiform encephalopathies? 1996;Ridley RM, Baker HF. Neurodegeneration 5(3):219-31.

The paradox of prion disease. 1996;Ridley RM, Baker HF. Prion Diseases 1-13-13.

Creutzfeldt-Jakob disease and bovine spongiform encephalopathy -Aetiology of scrapie in certain circumstances is not evidence against another aetiology in different circumstances. 1996;Ridley RM, Baker HF. Br Med J 312(7024):180

Failure to transmit bovine spongiform encephalopathy to marmosets with ruminant-derived meal. 1996;Ridley RM, Baker HF, Windle CP. Lancet 348(9019):56

NMR structure of the mouse prion protein domain PrP(121- 231). 1996;Riek R, Hornemann S, Wider G, Billeter M, Glockshuber R, Wuthrich K. Nature 382(6587):180-2.

Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity. 1996; Riesner D, Kellings K, Post K, Wille H, Serban H, Groth D, Baldwin MA, Prusiner SB. J Virol 70(3):1714-22.

Mad cow disease and Creutzfeldt-Jakob disease - Is there a link? 1996; Rist CE, Nielsen JO. Scand J Infect Dis 28(3):231-4.

Three-exon structure of the gene encoding the rat prion protein and its expression in tissues. 1996; Saeki K, Matsumoto Y, Hirota Y, Onodera T. Virus Genes 12(1):15-20.

Identification of a promoter region in the rat prion protein gene. 1996; Saeki K, Matsumoto Y, Onodera T. Biochem Biophys Res Commun 219(1):47-52.

Spectroscopic conformational studies of prion protein isoforms and the mechanism of transformation. 1996;Safar J. Semin Virol 7(3):207-14.

Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted Prp gene. 1996;Sakaguchi S, Katamine S, Nishida N, Moriuchi R, Shigematsu K, Sugimoto T, Nakatani A, Kataoka Y, Houtani T, Shirabe S, et al. Nature 380(6574):528-31.

Codon 200 mutation in a new family of Chilean origin with Creutzfeldt-Jakob disease. 1996;Salvatore M, Pocchiari M, Cardone F, Petraroli R, DAlessandro M, Galvez S, Brown P, Macchi G, Fieschi C, Colosimo C. J Neurol Neurosurg Psychiatry 61(1):111-2.

CT and MRI in iatrogenic and sporadic Creutzfeldt-Jakob disease: As far as imaging perceives. 1996; Santos JMG, Corbalan JAL, MartinezLage JF, Guillen JS. Neuroradiology 38(3):226-31.

Interaction of 68-kDa TAR RNA-binding protein and other cellular proteins with prion protein-RNA stem-loop. 1995;Scheffer U, Okamoto T, Forrest JMS, Rytik PG, Muller WEG, Schroder HC. J Neurovirology 1(5-6):391-8.

Spending on BSE research. 1996;Schellekens H. Nature 383(6597):211

Improvements in a competition assay to detect scrapie prion protein by capillary electrophoresis. 1996;Schmerr MJ, Goodwin KR, Cutlip RC, Jenny AL. J Chromatogr B Bio Med Appl 681(1):29-35.

Preclinical test for prion diseases. 1996;Schreuder BEC, vanKeulen LJM, Vromans MEW, Langeveld JPM, Smits MA. Nature 381(6583):563

Appearance of beta-5-microglobulin in rat hypothalamic magnocellular neurons after hypophysectomy. 1996;Shinoda M, Ohe Y, Katakai K, Kabeya K, Watanabe M, Miura T, Ishikawa K. Neuroendocrinology 64(4):268-73.

Panencephalitic Creutzfeldt-Jakob disease - Unusual presentation of magnetic resonance imaging and proton magnetic resonance spectroscopy. 1996;Shyu WC, Lee CC, Hsu YD, Lin JC, Lee JT, Lee WH, Tsao WL. J Neurol Sci 138(1-2):157-60.

The association between PrP and infectivity in scrapie and BSE infected mouse brain. 1996;Somerville RA, Dunn AJ. Arch Virol 141(2):275-89.

Prion analogues and twin studies in Parkinson's disease. 1996;Sommer SS, Rocca WA. Neurology 46(1):273-5.

Comparison of biochemical extraction techniques for the detection of scrapie-associated fibrils in the central nervous system of sheep naturally affected with scrapie. 1996;Stack MJ, Aldrich AM, Kitching AD, Scott AC. J Comp Pathol 115(2):175-84.

The diagnosis of bovine spongiform encephalopathy and scrapie by the detection of fibrils and the abnormal protein isoform. 1996;Stack MJ, Keyes P, Scott AC. Prion Diseases 85-103-103.

Prediction of future BSE spread. 1996;Stekel DJ, Nowak MA, Southwood TRE. Nature 381(6578):119

Spongiform encephalopathies in mainland China. 1996;Sun CK, Chong XQ, Huang YG. Lancet 348(9026):544

Objective quantification of prion protein in spinal cords of cases of Creutzfeldt-Jakob disease. 1996;Sutherland K, Goodbrand IA, Bell JE, Ironside JW. Anal Cell Pathol 10(1):25-35.

Quantification and analysis of the neuropathological features of Creutzfeldt-Jakob disease. 1996;Sutherland K, MacDonald ST, Ironside JW. J Neurosci Methods 64(1):123-32.

ts1-induced spongiform encephalomyelopathy: Physical forms of high-mobility DNA in spinal cord tissues of paralyzed mice are products of premature termination of reverse transcription. 1996;Szurek PF, Brooks BR. J Virol 70(4):2230-6.

Creutzfeldt-Jakob disease in a young woman. 1996;Tabrizi SJ, Scaravilli F, Howard RS, Collinge J, Rossor M. Lancet 347(9006):945-8.

Methods for studying prion protein amyloid. 1996;Tagliavini F, Prelli F, Giaccone G, Forloni G, Salmona M, Piccardo P, Ghetti B, Frangione B, Bugiani O. Prion Diseases 265-283-283.

Analysis of PrPc mRNA by in situ hybridization in brain, placenta, uterus and testis of rats. 1995;Tanji K, Saeki K, Matsumoto Y, Takeda M, Hirasawa K, Doi K, Onodera T. Intervirology 38(6):309-15.

Transmission of human prion diseases to rodents. 1996;Tateishi J. Semin Virol 7(3):175-80.

Experimental transmission of Creutzfeldt-Jakob disease and related diseases to rodents. 1996;Tateishi J, Kitamoto T, Hoque MZ, Furukawa H. Neurology 46(2):532-7.

Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein. 1996;Tatzelt J, Maeda N, Pekny M, Yang SL, Betsholtz C, Eliasson C, Cayetano J, Camerino AP, Dearmond SJ, Prusiner SB. Neurology 47(2):449-53.

Inactivation of the causal agents of Creutzfeldt-Jakob disease and other human prion diseases. 1996;Taylor D. Brain Pathol 6(2):197

Creutzfeldt-Jakob disease. 1996; Taylor DM. Lancet 347(9011):1333

The response of the 22A strain of scrapie agent to microwave irradiation compared with boiling. 1996;Taylor DM, Diprose MF. Neuropathol Appl Neurobiol 22(3):256-8.

Exposure to autoclaving or sodium hydroxide extends the dose-response curve of the 263K strain of scrapie agent in hamsters. 1996;Taylor DM, Fernie K. J Gen Virol 77:811-813:811-3.

Scrapie infection can be established readily through skin scarification in immunocompetent but not immunodeficient mice. 1996;Taylor DM, McConnell I, Fraser H. J Gen Virol 77:1595-1599:1595-9.

Interactions between wild-type and mutant prion proteins modulate neurodegeneration transgenic mice. 1996;Telling GC, Haga T, Torchia M, Tremblay P, Dearmond SJ, Prusiner SB. Gene Develop 10(14):1736-50.

Transgenic mice in amyloid research: An interpretive review. 1996;Teng MH, Buxbaum JN. Amyloid 3(3):187-208.

Precocious loss of physiological sleep in a case of Creutzfeldt-Jakob disease: A serial polygraphic study. 1995;Terzano MG, Parrino L, Pietrini V, Mancia D, Spaggiari MC, Rossi G, Tagliavini F. Sleep 18(10):849-58.

Altered circadian activity rhythms and sleep in mice devoid of prion protein. 1996;Tobler I, Gaus SE, Deboer T, Achermann P, Fischer M, Rulicke T, Moser M, Oesch B, McBride PA, Manson JC. Nature 380(6575):639-42.

Amyloidosis, protein conformation dynamics and neurological diseases. 1996;Tranchant C, Rodier G, Schmitthaeusler R, Warter JM. Rev Neurol 152(3):153-7.

Spending on BSE research. 1996;Turner JZ. Nature 383(6597):211

Handling the BSE epidemic in Great Britain. 1996;Tyrrell DAJ, Taylor KC. Prion Diseases 175-198-198.

Prions and hospital infections. 1996;vanAsten JAAM, Geertsma RE, Dorpema JW. Lancet 347(9006):966-7.

BSE and risk to humans. 1996;vanBekkum DW, Heidt PJ. Nature 382(6592):574

Hypokinesia and presenile dementia in a Dutch family with a novel insertion in the prion protein gene. 1995;vanGool WA, Hensels GW, Hoogerwaard EM, Wiezer JHA, Wesseling P, Bolhuis PA. Brain 118:1565-1571:1565-71.

Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie. 1996;vanKeulen LJM, Schreuder BEC, Meloen RH, MooijHarkes G, Vromans MEW, Langeveld JPM. J Clin Microbiol 34(5):1228-31.

Biochemistry - Yeast prions: DNA-free genetics? 1996;Vogel G. Science 273(5275):580

A model for prion protein dimerisation based on alpha- helical packing. 1996;Warwicker J, Gane PJ. Biochem Biophys Res Commun 226(3):777-82.

Recombinant prion protein rPrP27-30 from Syrian golden hamster reveals proteinase K sensitivity. 1996;Weiss S, Rieger R, Edenhofer F, Fisch E, Winnacker EL. Biochem Biophys Res Commun 219(1):173-9.

Molecular biology of transmissible spongiform encephalopathies. 1996;Weissmann C. FEBS Lett 389(1):3-11.

Transgenic approaches to prion ''species-barrier'' effects. 1996;Westaway D. Prion Diseases 251-263-263.

For protein misassembly, it's the ''I'' decade. 1996;Wetzel R. Cell 86(5):699-702.

Creutzfeldt-Jakob disease and bovine spongiform encephalopathy -Advisory committee's conclusion was based on ''absence of any credible alternative''. 1996;Wickham A. Br Med J 312(7037):1038

Potential transmission of BSE via medicinal products - Patients can be reassured that measures are in place to reduce risk. 1996;Wickham EA. Br Med J 312(7037):988-9.

[PSI] and [URE3] as yeast prions. 1995;Wickner RB, Masison DC, Edskes HK. Yeast 11(16):1671-85.

[URE3] and [PSI] as prions of Saccharomyces cerevisiae: Genetic evidence and biochemical properties. 1996;Wickner RB, Masison DC, Edskes HK. Semin Virol 7(3):215-23.

Prions. 1996;Wieland S, vonWeizsacker F, Blum HE. Dtsch Med Wochenschr 121(30):949-52.

Creutzfeldt-Jakob disease and bovine spongiform encephalopathy -Cohort study of cows is in progress. 1996;Wilesmith JW. Br Med J 312(7034):843

Bovine spongiform encephalopathy - Methods of analyzing the epidemic in the United Kingdom. 1996;Wilesmith JW. Prion Diseases 155-173-173.

Surveillance of prion diseases in humans. 1996;Will RG. Prion Diseases 119-137-137.

Separation of scrapie prion infectivity from PrP amyloid polymers. 1996;Wille H, Zhang GF, Baldwin MA, Cohen FE, Prusiner SB. J Mol Biol 259(4):608-21.

Circumventing tolerance to generate autologous monoclonal antibodies to the prion protein. 1996;Williamson RA, Peretz D, Smorodinsky N, Bastidas R, Serban H, Mehlhorn I, Dearmond SJ, Prusiner SB, Burton DR. Proc Natl Acad Sci USA 93(14):7279-82.

Bovine spongiform encephalopathy - Disease is due to pressure on farming industry - Media coverage had short- lived effect on beef consumption by. 1996;Wilson S, McLeod S, Gillies A, Carter Y. Br Med J 313(7050):171

Genetic basis of Creutzfeldt-Jakob disease in the United Kingdom: A systematic analysis of predisposing mutations and allelic variation in the PRNP gene. 1996;Windl O, Dempster M, Estibeiro JP, Lathe R, deSilva R, Esmonde T, Will R, Springbett A, Campbell TA, Sidle KCL, et al. Hum Genet 98(3):259-64.

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines. 1996;Wischik CM, Edwards PC, Lai RYK, Roth M, Harrington CR. Proc Natl Acad Sci USA 93(20):11213-8.

Scientists find low level transmission of BSE. 1996;Wise J. Br Med J 313(7053):317

Mites as vectors for scrapie. 1996;Wisniewski HM, Sigurdarson S, Rubenstein R, Kascsak RJ, Carp RI. Lancet 347(9008):1114

Molecular biology of brain aging and neurodegenerative disorders. 1996;Wisniewski T, Frangione B. Acta Neurobiol Exp 56(1):267-79.

Decreased receptor-mediated calcium response in prion- infected cells correlates with decreased membrane fluidity and IP3 release. 1996;Wong K, Qiu Y, Hyun W, Nixon R, VanCleff J, SanchezSalazar J, Prusiner SB, Dearmond SJ. Neurology 47(3):741-50.

Histopathological changes in the islets of Langerhans in hamsters infected with the 139H strain of scrapie: Semi- thin section study. 1996;Ye X, Carp RI. Histol Histopathol 11(1):161-70.

Histopathological changes in the pituitary glands of female hamsters infected with the 139H strain of scrapie. 1996;Ye X, Carp RI. J Comp Pathol 114(3):291-304.

Margination and diapedesis of inflammatory cells in the islets of Langerhans in hamsters infected with the 139H strain of scrapie. 1996;Ye X, Carp RI. J Comp Pathol 114(2):149-63.

Detection of species specific epitopes of mouse and hamster prion proteins (PrPs) by anti-peptide antibodies. 1996;Yokoyama T, Itohara S, Yuasa N. Arch Virol 141(3-4):763-9.

Creutzfeldt-Jakob disease in a beef farmer. 1996;Young GR, Fletcher NA, Zeidler M, Estibeiro KL, Ironside JW. Lancet 348(9027):610-1.

Creutzfeldt-Jakob disease and bovine spongiform encephalopathy -Magnetic resonance imaging is not a sensitive test for Creutzfeldt-Jakob disease. 1996;Zeidler M, Will RG, Ironside JW, Sellar R, Wardlaw J. Br Med J 312(7034):844

Prionitisides A and B, two phenolic glycosides from Salvia prionitis. 1996;Zhao LM, Liang XT, Li LN. Phytochemistry 42(3):899-901.

Last modified: January 27, 1998